TRAIL S1

Louis Pasteur Center for Medical Research, a public interest incorporated foundation was established by the late Dr. Tsunatato Kishida in 1986 following the spirit of Louis Pasteur, a French scientist. Since it's establishment, we have passionately researched on immunity focusing on interferon and studied lactic acid bacteria as probiotics which bring a good effect to our health. Animal-based bacteria were so common when it comes to lactic acid bacteria at that time. However, Dr. Tsunatato Kishida focused on traditional fermented foods in Kyoto, Japan such as "Suguki" and "Shibazuke" pickles to observe plant-based lactic acid bacteria, instead. Lactobacillus Brevis was found in 1993 thanks to his effort. It is a kind of lactic acid bacteria from pickled Suguki. Therefore, Lactobacillus Brevis has a strong bond with Japanese food culture. We didn't forget our curiosity even after succeeding to find Brevis. This time, our center found a new type of lactic acid bacteria based in out 15-year research. TRAIL S-1! It is also a kind of plant-based lactic acid bacteria from the same bacterial strain as Lactobacillus Brevis, Suguki pickles. As a result of co-research by our center and Kyoto Prefectural University of Medicine, it is reviewed that this type of lactic acid bacteria has the unique charactaristic to activate TRAIL production. By the way, TRAIL is one of cytokines relating to our immunity and causes cancer cells' apoptosis, programed self-deaths of bad cells. This finding of us is on the journal called FEBS letters. It was accepted as the first scientific report which showed the relationship between lactic acid bacteria and TRAIL (FEBS Letters 584 (2010) 577-582). As mentioned above, TRAIL S-1 is a new type of lactic acid bacteria highly activating TRAIL.